evaluation of rs3102735 and rs2073617 osteoprotegerin gene polymorphisms and the risk of childhood acute lymphoblastic leukemia in zahedan southeast iran.

introduction: osteoprotegerin (opg), a soluble decoy receptor secreted by osteoblasts, binds rank-l, preventing stimulation of osteoclastogenesis. in the present study we aimed to investigate the impact of opg variants and susceptibility to childhood acute lymphocytic leukemia (all) in a sample of iranian population. methods: this case-control study was done on 98 all and 124 healthy children. we genotyped the polymorphisms using tetra-primer arms-pcr (t-arms-pcr). results: our findings showed that neither rs3102735 nor rs2073617 variants were associated with all in a sample of iranian population. concerning rs3102735 polymorphism, the age of all predispositions was significantly higher in tc+cc genotype than tt genotype (p=0.032). furthermore, the csf involvement was significantly higher in all subjects carrying tc+cc genotype (p=0.044). conclusion: we found no association between opg (rs3102735, rs2073617) gene polymorphisms and risk of childhood all. further studies with larger sample sizes and various ethnicities are necessary to verify our findings.